Doctoral Student in DNA Nanotechnology and Cell Signal Regulation

About the role

Four-year fully funded PhD at Karolinska Institutet (Solna campus) on DNA nanotechnology and Notch cell signal regulation. The project maps molecular interactors of Notch signalling, uses advanced imaging to characterise signalling dynamics, and engineers DNA nanodevices that can be validated in living organisms. Deadline: 10 June 2026.

Responsibilities

• Map and functionally characterise molecular interactors of the Notch signalling pathway using gene editing and proteomic approaches.
• Design and build DNA nanostructures (DNA origami, DNA frameworks) to probe and perturb cell signalling at the nanoscale.
• Perform advanced imaging, including super-resolution and live-cell fluorescence microscopy.
• Validate DNA nanodevice function in cell culture and in vivo model systems.
• Write manuscripts and present findings at international conferences.
• Complete the KI doctoral coursework programme.

Requirements

• Master’s degree (240+ higher education credits, at least 60 at advanced level) in molecular biology, biochemistry, biophysics, chemistry, biotechnology, or an equivalent field.
• Practical laboratory skills: cell culture, molecular cloning, microscopy.
• Fluent written and spoken English (Swedish is not required).
• Ability to work both independently and as part of an interdisciplinary team.

Nice to have

• Prior experience in DNA nanotechnology or structural DNA design.
• Familiarity with super-resolution microscopy techniques (STORM, PALM, STED).
• Background in GPCR or receptor tyrosine kinase signalling pathways.
• A first-author publication or preprint.

How to apply

Apply through the Nature Careers portal at the apply link above. Upload a single PDF containing your CV, a personal letter (max 1 page), academic transcripts, MSc thesis or draft, contact details for two references, and a description of any prior research experience. Applications close 10 June 2026.